Mount Sinai to host a free informational seminar for patients and families with MEN types 1 and 2. Please click here to registerMore
The Mount Sinai Division of Endocrinology highlights the Adrenal Center in their recently published news letter. Read more: 2016 Specialty Report_EndocrinologyMore
A renowned surgical neuro-oncologist Constantinos (Costas) G. Hadjipanayis, is Professor and Chair of the Department of Neurosurgery at Mount Sinai Beth Israel in New York City, New York. He is also Director of Neurosurgical Oncology for the Mount Sinai Health System and Director of the Brain Tumor Nanotechnology Laboratory in the Tisch Cancer Institute.
Both as a neurosurgeon and an NIH-funded scientist, Dr. Hadjipanayis is recognized as a neuro-oncology pioneer for driving advancements in the therapy and surgical management of brain tumors. He is also an internationally recognized expert in minimally invasive, neuro-endoscopic procedures to treat disorders in the brain.
Dr. Hadjipanayis’ interests include surgery and experimental therapeutics for malignant brain tumors, neuro-endoscopy for pituitary tumors and especially colloid cysts, for which his published experience is one of the largest reported. In addition he performs microsurgery and radiosurgery for tumors of the skull base and spinal cord.More
On Jan 13, 2016, Dr Inabnet gave the inaugural Mansour lecture in endocrine surgery at George Washington University Medical Center in Washington DC. His lecture was entitled: Pancreatic Neuroendocrine Tumors: Advancing Innovation, Quality and Translational Science.More
Dr Alice Levine, Co-Director of the Mount Sinai Adrenal Center, edits special edition of Endocrinology and Metabolism Clinics of North America on Adrenal disorders.
1. Genetics and the clinical approach to adrenal cortical neoplasia: connecting the dots. Levine AC. Endocrinol Metab Clin North Am. 2015 Jun;44(2):xvii-xviii. doi: 10.1016/j.ecl.2015.03.002. No abstract available. PMID: 26038212
2. Adrenal cortical neoplasia. LeRoith D. Endocrinol Metab Clin North Am. 2015 Jun;44(2):xiii-xv. doi: 10.1016/j.ecl.2015.03.003. No abstract available.
3. Surgical Management of Adrenocortical Carcinoma. Fernandez Ranvier GG, Inabnet WB 3rd. Endocrinol Metab Clin North Am. 2015 Jun;44(2):435-452. doi: 10.1016/j.ecl.2015.02.008. Epub 2015 Mar 17. Review.
4. Adrenocortical Carcinoma. Baudin E. Endocrinol Metab Clin North Am. 2015 Jun;44(2):411-434. doi: 10.1016/j.ecl.2015.03.001. Review. PMID: 26038209
5. Adrenocortical Carcinoma: Review of the Pathologic Features, Production of Adrenal Steroids, and Molecular Pathogenesis. Nakamura Y, Yamazaki Y, Felizola SJ, Ise K, Morimoto R, Satoh F, Arai Y, Sasano H. Endocrinol Metab Clin North Am. 2015 Jun;44(2):399-410. doi: 10.1016/j.ecl.2015.02.007. Review.
6. Management of Adrenal Tumors in Pregnancy. Eschler DC, Kogekar N, Pessah-Pollack R. Endocrinol Metab Clin North Am. 2015 Jun;44(2):381-397. doi: 10.1016/j.ecl.2015.02.006. Review.
7. Adrenal Mild Hypercortisolism. Goddard GM, Ravikumar A, Levine AC.
Endocrinol Metab Clin North Am. 2015 Jun;44(2):371-379. doi: 10.1016/j.ecl.2015.02.009. Review. PMID: 26038206
8. Primary Aldosteronism: Challenges in Diagnosis and Management.
Galati SJ. Endocrinol Metab Clin North Am. 2015 Jun;44(2):355-369. doi: 10.1016/j.ecl.2015.02.010. Review.PMID: 26038205
9. Adrenal Incidentalomas: A Disease of Modern Technology Offering Opportunities for Improved Patient Care. Ioachimescu AG, Remer EM, Hamrahian AH. Endocrinol Metab Clin North Am. 2015 Jun;44(2):335-354. doi: 10.1016/j.ecl.2015.02.005. Review. PMID: 26038204
10. The Genetics of Adrenocortical Tumors. Espiard S, Bertherat J.
Endocrinol Metab Clin North Am. 2015 Jun;44(2):311-334. doi: 10.1016/j.ecl.2015.02.004. Review. PMID: 26038203
11. Animal Models of Adrenocortical Tumorigenesis. Galac S, Wilson DB.
Endocrinol Metab Clin North Am. 2015 Jun;44(2):297-310. doi: 10.1016/j.ecl.2015.02.003. Review. PMID: 26038202
12. Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia. Turcu AF, Auchus RJ. Endocrinol Metab Clin North Am. 2015 Jun;44(2):275-296. doi: 10.1016/j.ecl.2015.02.002. Review. PMID: 26038201
13. Development of Adrenal Cortex Zonation. Xing Y, Lerario AM, Rainey W, Hammer GD. Endocrinol Metab Clin North Am. 2015 Jun;44(2):243-274. doi: 10.1016/j.ecl.2015.02.001. Review. PMID: 26038200More
Dr Hyun Suh joins the Adrenal Center team in the Spring 2015. Dr Suh completed his general surgery residency at Boston University, followed by a 1-year fellowship in Endocrine Surgery at Massachusetts Medical Center. He then spent 6 months at Seoul National Hospital to acquire additional training in robotic endocrine surgery.More
Neuroendocrine tumors (NET) are rare neoplasms of neuroendocrine origin. Neuroendocrine tumors are solid malignant tumors that arise from dispersed neuroendocrine cells found throughout the body. They are well known for their heterogeneity which makes it difficult to obtain uniform clinical data and establish universal guidelines for the diagnosis and treatment of NETs. NETs are characterized by overexpression of somatostatin receptors, which can be visualized and targeted by radiolabeled somatostatin analogues. 111In-diethylenetriaminepentaacetic acid-octreotide scintigraphy (111In-Octreotide) with single photon emission tomography (SPECT) is currently the standard imaging modality for evaluating patients with NETs. 111In Octreotide is the only FDA approved radiopharmaceutical available on the market for assessing the extent of involvement by NETs at both staging and follow up periods. However, the sensitivity of this imaging modality is lower compared to the positron emission tomography (PET) radiotracer 68Ga-DOTA -Tyr3]octreotide (68Ga-DOTA-TOC). Importantly, the radiation exposure of 68Ga-DOTATOC PET is lower than that of 111In Octreotide and also the imaging with 68Ga-DOTATOC PET scan yields fast read-outs on the same day compared to 24-48 hour read-outs with 111In Octreotide scan. These advantages make the 68Ga labeled somatostatin analog more attractive from both the patient and management perspectives. The improved resolution and quantitation of uptake obtained with Ga-68 DOTATOC PET should provide a more accurate assessment of somatostatin receptor density, which will lead to a more accurate prediction of treatment response to somatostatin analogues.More
THE SPECIALIST: Dr. William Inabnet
A professor of surgery at Mount Sinai, Dr. William Inabnet is an endocrine and metabolic surgeon who who has been in the field for 15 years. Through the Adrenal Center, he oversees the care of more than 400 patients with adrenal nodules a year.
WHO’S AT RISK
Whether rooting for your favorite team or simply running late for a meeting, adrenaline is part of daily life for most Americans — but that doesn’t mean we spend much time thinking about where it comes from.
“Located above the kidneys, the adrenal glands produce a series of hormones that influence blood pressure control, electrolyte balance and stress response, including adrenaline — functions essential for life,” says Inabnet. “When nodules form on the adrenal glands, most of them require no treatment — but every nodule warrants a workup to rule out something more serious, including adrenal cancer.”More
Cristina Speirs, 22, was a self-proclaimed “health freak” during her senior year of college, which is all the more reason she would have never guessed that her body would betray her the way it did.
She exercised six times a week, taught hot yoga classes and drank a lot of water throughout the day to stay hydrated. So, when she stopped feeling tired and started getting up more frequently in the middle of the night to go to the bathroom, she didn’t think anything of it.
“I had a lot of energy,” Speirs said. “I wasn’t sleeping. … I was always on the go. I was never tired.”
Read about a woman whose tumor made her seem drunk.
She would eventually learn that she had a tumor the size of an orange on her adrenal gland, and that it was making the hormones that kept her up at night.
Doctors first noticed a problem at Speirs’ annual checkup in the fall of 2012 when they found that her potassium levels were low, but her blood pressure was “through the roof.”
But they had no idea what was causing the strange symptoms.
“That really freaked me out because them not knowing what’s wrong with me — they’re doctors, you know?” Speirs said.
A cardiologist quickly determined there was nothing wrong with her heart, but Speirs’ mother suggested a renal sonogram to check her kidneys.
Speirs noticed that the sonogram technician spent a long time lingering over her kidneys and looked confused. Alarmed, Speirs asked what was wrong. The technician told Speirs she needed an MRI right away because she suspected Speirs had one large combined kidney instead of two normal-sized kidneys.
“She said, ‘You don’t feel anything?'” Speirs said. “I was like, ‘No. I feel fine.'”
The MRI would reveal that Speirs had normal kidneys. It was a 10-centimeter tumor that the technician was seeing.
“I was in complete shock,” she said, explaining that she phoned her parents immediately to tell them that she’d need surgery. “Then, I got so upset honestly. I had no idea where this came from.”
Then she met Dr. William Inabnet, co-director of the Adrenal Center at Mount Sinai Hospital in New York City. Upon learning that Speirs’ tumor was producing two hormones — cortisol and aldosterone — he feared that the tumor was cancerous.
On Oct. 18, 2012, he scheduled surgery to remove it the following Halloween. Surgery on the spooky holiday made Speirs feel superstitious, but she didn’t say anything.
And then Superstorm Sandy hit on Oct. 29, and the hospital was thrown into chaos. Evacuated patients from NYU Langone Medical Center were sent to Mount Sinai, and doctors from different hospitals were working side by side to help the sickest patients.
The hospital was packed, and most regular surgeries were canceled.
“We had to really negotiate and find a team that could staff the case,” Inabnet said, adding that he needed nurses, anesthesiologists and others to operate.
Speirs’ parents kept the reality of the storm mostly hidden from her, but before she handed her glasses to her father to be wheeled off into the operating room, she saw all the beds of patients displaced by Sandy.
“I was just kind of a little teary,” she said, remembering the cold of the operating room and the little warmth offered by the hospital gown.More